BioScience Trends. 2008;2(2):74-76. (DOI: )
On the temperature dependence of the unbound drug fraction in plasma: Ultrafiltration method may considerably underestimate the true value for highly bound drugs.
Berezhkovskiy LM
SUMMARY
The value of the unbound drug fraction in plasma is a common characteristic required for drug discovery and development. The communication considers an important possibility that the unbound drug fraction at physiological temperature (37
KEYWORDS: Protein binding, Unbound drug fraction, Equilibrium dissociation constant, Ultrafiltration, Pharmacokinetics, Thermodynamics
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