BioScience Trends. 2008;2(2):128-135. (DOI: )

Iontophoretic delivery of 5-fluorouracil through excised human stratum corneum.

Singh BN, Jayaswal SB

The objective of this study was to determine the effects of ionization, current density and penetration enhancers on the iontophoretic delivery of 5-fluorouracil (5-FU) through excised human stratum corneum (HSC). The iontophoretic (cathodal) transport of 5-FU was assessed in vitro at three physiologically relevant pH values of 5.0, 7.4 and 8.0, at various levels of current density ranging between 0.15 to 0.98 mA/cm2, and in the presence of suitable penetration enhancers, namely Azone

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