Discovery of N-hydroxy-4-(1H-indol-3-yl)butanamide as a histone deacetylase inhibitor.

BioScience Trends. 2016;10(3):163-166. (DOI: 10.5582/ddt.2016.01031)

Discovery of N-hydroxy-4-(1H-indol-3-yl)butanamide as a histone deacetylase inhibitor.

Bian J, Luan YP, Wang CB, Zhang L

SUMMARY

The indoles plant growth hormones have exhibited potentially antitumor activities. However, the targets of these indoles have not been clearly elucidated. By introduction of hydroxamic acid group to the structure of indolebutyric acid, the derived molecule (IBHA) exhibited potent HDAC2 (IC50 value of 0.32

KEYWORDS: HDACs inhibitor, indolebutyric acid, hydroxamic acid, docking, pharmacophore model

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