BioScience Trends. 2017;11(3):118-125. (DOI: 10.5582/ddt.2017.01016)
Sulfonyl phosphonic 1,4-dithia-7-azaspiro[4,4]nonane derivatives as matrix metalloproteinase inhibitors: Synthesis, a docking study, and biological evaluation.
Zhang H, Li X, Wang XJ, Xu WF, Zhang J
SUMMARY
A series of novel sulfonyl phosphonic 1,4-dithia-7-azaspiro[4,4]nonane derivatives were designed, synthesized, and assayed for their activity against matrix metalloproteinase-2 (MMP-2). Results indicated that all of the compounds exhibited moderate inhibitory activity against MMP-2 compared to LY52 (the control) (IC50 = 0.95
KEYWORDS: Matrix metalloproteinase-2, 1,4-dithia-7-azaspiro[4,4]nonane derivatives, inhibitors, synthesis
Full Text: 
