BioScience Trends. 2017;11(5):253-258. (DOI: 10.5582/ddt.2017.01050)
Skin permeability of tulobuterol in two transdermal formulations and their followability.
Takizawa Y, Goto T, Sato S, Ohmori N, Mori K, Shimada Y, Chen K, Miyagi T, Fukai F
SUMMARY
Various generic transdermal formulations of tulobuterol containing rubber and acrylate base polymers are commercially available in Japan. However, none of the formulations have been compared directly with respect to the skin permeability of tulobuterol and to their follow ability. Tulobuterol Tape Sawai of rubber base and Tulobuterol Tape NP of acrylate base were used to conduct the in vitro 24-hour skin permeability test of tulobuterol at receiver solution temperatures of 32
KEYWORDS: Tulobuterol, transdermal, rubber base, acrylate base, intact skin, abraded skin