BioScience Trends. 2017;11(6):293-299. (DOI: 10.5582/ddt.2017.01072)

Improved systemic delivery of insulin by condensed drug loading in a dimpled suppository.

Matsumoto A, Murakami K, Watanabe C, Murakami M

The development of peptide therapeutics owing to the advances in biotechnology has overcome some unmet medical needs; however, the route of administration is still limited to injections. Systemic delivery of insulin via an enteral route remains a great challenge due to its instability and low mucosal permeability. In this study, we investigated the effect of drug condensation in a suppository on the efficacy of insulin after rectal administration. Suppositories with dimples are prepared by a mold method using a hard fat (Suppocire

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