BioScience Trends. 2018;12(3):122-125. (DOI: 10.5582/ddt.2018.01028)

Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system.

Ishii M, Matsumoto Y, Sekimizu K


SUMMARY

Cyclodextrins (CyDs) are cyclic oligosaccharides consisting of six to eight glucose residues. Administration of ?-CyD (six glucose residues) inhibits sucrose-induced hyperglycemia in humans. Here we show that oral administration of ?-CyD and dimethyl ?-CyD suppresses sucrose-induced hyperglycemia in an in vivo evaluation system using silkworms. On the other hand, ?-CyD (seven glucose residues), ?-CyD (eight glucose residues), and their derivatives did not show the suppressive effect. These findings suggest that dimethyl ?-CyD is a new inhibitor against sucrose-induced hyperglycemia and the silkworm system is useful for evaluation of suppressive activities of ?-CyD derivatives against postprandial hyperglycemia.


KEYWORDS: Cyclodextrin, hyperglycemic activity, silkworm, sucrose-induced hyperglycemia

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