BioScience Trends. 2009;3(1):27-36. (DOI: )

Enhancement of the dissolution profile of Tenoxicam by a solid dispersion technique and its analytical evaluation using HPLC.

Darwish MK, Foad MM

The aim of the present study was to improve the dissolution, and therefore the bioavailability, of poorly water-soluble tenoxicam. Solid dispersions consisting of tenoxicam with two different types of polymers were prepared. The first type were PVP₃₀ and ?-cyclodextrin and the second type were two superdisintegrants, explotab and croscarmellose sodium. A solid dispersion with an explotab ratio of 1:1 (F₈) had the best dissolution profile compared to all of the prepared solid dispersions as well as the pure drug, which was then formulated into tablets (T₂F₈). T₂F₈ had far better dissolution than commercial tablets, releasing only 28.3% of the drug, while T₂F₈ exhibited 96.5% drug release in 20 min. T₂F₈ was subjected to analytical validation as well as stability studies. The formulation was found to be stable after storage at 40

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