BioScience Trends. 2007;1(1):23-29. (DOI: )
Target validation: A door to drug discovery.
Chen XP, Du GH
SUMMARY
From ancient times to today, drug discovery transitioned from serendipity to rationality over its long history. Proper drug target selection and validation are crucial to the discovery of new drugs. This review discusses the definition of drug targets and proposes several characteristics for drug targets. The limitations of the term
KEYWORDS: Drug discovery, drug target, drug target validation, high-throughput screening, lectin-like oxidized low-density lipoprotein receptor-1
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