BioScience Trends. 2009;3(5):228-233. (DOI: )

Vaginal delivery of protein drugs in rats by gene-transformed Lactococcus lactis.

Kaushal G, Shao J

A probiotic bacterium, Lactococcus lactis subsp. lactis (L. lactis) transformed with plasmid ss80, which made it capable of synthesizing and secreting ?-lactamase, a 29 kDa protein, was used to deliver ?-lactamase via vaginal route. The vaginal absorption of ?-lactamase in rats was studied when delivered by this L. lactis system and compared to the ?-lactamase solution with or without the untransformed L. lactis. The vaginal administration of 1.2

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