BioScience Trends. 2010;4(2):93-99. (DOI: )

Stability, bioavailability, and ulcerative activity of diclofenac sodium-mastic controlled release tablets.

Nouh AT, Abd El-Gawad AH, Guda TK


SUMMARY

Controlled release tablets containing 50 mg diclofenac sodium (DS) and 40% mastic with other natural additives were prepared. Drug release was examined and stability was studied using non-isothermal and isothermal thermogravimetric analysis (TGA). The bioavailability of two controlled release tablet formulations was studied and compared to that of commercial tablets, and rabbit stomachs were also histologically examined 24 h after administration of the various tablets. Additives of pectin and sodium alginate indicated the controlled release profile of the drug. Non-isothermal TG revealed two stages of thermal decomposition for all formulations. Isothermal TG revealed that degradation of the drug in the tablet formulations follows first-order kinetics. The obtained degradation rate constants at various temperatures were plotted according to the Arrhenius equation. The degradation rate constant at 25


KEYWORDS: Diclofenac sodium, natural additives, tablets, dissolution rate, ulcerative activity, in vivo studies

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