BioScience Trends. 2011;5(1):41-52. (DOI: 10.5582/ddt.v5.1.41)
Validated spectrophotometric methods for determination of some oral hypoglycemic drugs.
Farouk M, Abdel-Satar O, Abdel-Aziz O, Shaaban M
SUMMARY
Four accurate, precise, rapid, reproducible, and simple spectrophotometric methods were validated for determination of repaglinide (RPG), pioglitazone hydrochloride (PGL) and rosiglitazone maleate (RGL). The first two methods were based on the formation of a charge-transfer purple-colored complex of chloranilic acid with RPG and RGL with a molar absorptivity 1.23
KEYWORDS: Repaglinide, pioglitazone hydrochloride, rosiglitazone maleate, charge-transfer complex, ionpair complex, derivative spectrophotometry, difference spectrophotometry, stability-indicating method
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