BioScience Trends. 2015;9(4):303-309. (DOI: 10.5582/ddt.2015.01053)

Fabrication of porous ethyl cellulose microspheres based on the acetone-glycerin-water ternary system: Controlling porosity via the solvent-removal mode.

Murakami M, Matsumoto A, Watanabe C, Kurumado Y, Takama M


SUMMARY

Porous ethyl cellulose (EC) microspheres were prepared from the acetone-glycerin-water ternary system using an oil/water (O/W)-type emulsion solvent extraction method. The O/W type emulsion was prepared using acetone dissolved ethyl cellulose as an oil phase and aqueous glycerin as a water phase. The effects of the different solvent extraction modes on the porosity of the microspheres were investigated. The specific surface area of the porous EC microspheres was estimated by the gas adsorption method. When the solvent was extracted rapidly by mixing the emulsion with water instantaneously, porous EC microspheres with a maximum specific surface area of 40.7


KEYWORDS: Porous microspheres, ethyl cellulose, acetone-glycerin-water ternary system, phase separation, solvent extraction

Full Text: